33-Year-Old Woman With Marked Eosinophilia


Fungal Diseases

Disease

Symptoms

Fungi

Allergic Aspergillus Allergic Alveolitis

Hypersensitivity pneumonia in people exposed to large numbers of Aspergillus

Malaise, chills, fever, cough, SOB, and myalgias 4-8 hours after antigen exposure

Self-limited

Aspergillus

Allergic Aspergillus Allergic Bronchopulmonary Aspergillosis (ABPA)

Persons w/ preexisting asthma become colonized in airways

Eosinophilia

Fleeting pulm infiltrates b/c of bronchial plugging

Immediate type skin test response to Aspergillus a-g

Incr IgE and IgG

Can progress to irreversible obstuctive lung disease

Aspergillus

Aspergilloma (fungus ball)

Pts w/ prior lung disease resulting in residual cavities

May be no resp symptoms

May developed hemoptysis

Films show round or oval cavitary mass that may be mobile on a stalk, may have a cresent of air around it

Aspergillus

Invasive pulmonary aspergillosis

IC pts w/ prolonged, profound granulocytopenia

Inhalation


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